Nature chemical biology
Engineering metazoan fatty acid synthase to control chain length applied in yeast.
Damian L Ludig, Xiaoxin Zhai, Alexander Rittner, Christian Gusenda, Maximilian Heinz, Svenja Berlage, Ning Gao, Adrian J Jervis, Yongjin J Zhou, Martin Grininger
Published: 202610.1038/s41589-025-02105-w
Abstract
Metazoan fatty acid (FA) synthases (mFASs) facilitate the de novo synthesis of C16- and C18-FAs through iterative extensions within the FA cycle and hydrolytic release. Here we re-engineer mFAS to fine-tune the interplay between FA extension and FA h…
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