Nature chemical biology
Molecular basis of SAM-AMP synthesis and degradation in the type III-B CRISPR-Cas system.
Benzhen Duan, Xiaohui Jin, Xiaoman An, Yang Xiao, Qianxi Yang, Hongyu Zhao, Yunxiao Huang, Jingwen Wang, Qian Wang, Fenglei Du, Lu Lu, Lei Sun, Zhenguo Chen, Baoyu Zhao
Published: 202510.1038/s41589-025-02075-z
Abstract
Upon sensing nonself target RNA, the CorA-associated type III-B CRISPR-Cas system catalyzes S-adenosyl methionine (SAM) and ATP to synthesize SAM-AMP, which activates the effector CorA and triggers immune responses. SAM-AMP can be degraded by NrN and…
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