Nature chemical biology
Site-resolved energetic information from HX-MS experiments.
Chenlin Lu, Malcolm L Wells, Andrew Reckers, Savannah K McBride, Anum Glasgow
Published: 202510.1038/s41589-025-02049-1
Abstract
High-resolution energetic information about protein conformational ensembles is essential for understanding protein function, yet remains challenging to obtain. Here we present PIGEON-FEATHER, a method for calculating ensemble free energies of openin…
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