Nature chemical biology
Stabilization of AFF1 by PARylation ensures transcriptional restart after DNA damage.
Feifeng Zhu, Huanyi Fu, Wenxuan Zhu, Chengyu Li, Min Yang, Zeming Feng, Yangqing Shao, Zhuo Li, Yafei Guo, Mengting Huang, Yitong Zhang, Yaohui He, Yi Lu, Zhibing Wu, Qiang Zhou
Published: 202510.1038/s41589-025-02045-5
Abstract
Precise control of transcription is essential for cell survival under stress conditions, including DNA damage. While mechanisms of DNA damage-induced transcriptional silencing are well characterized, how transcription resumes remains less understood.…
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