Nature geneticsHumansLung NeoplasmsMutationAdenocarcinoma of LungGene Expression Regulation
Passenger mutations link cellular origin and transcriptional identity in human lung adenocarcinomas.
Sukanya Panja, Padmaja Mantri, Kofi Ennu Johnson, Juan Sebastian Andrade-Martinez, Soo-Ryum Yang, Aditya Deshpande, Huasong Tian, Shaham Beg, Kentaro Ohara, Alessandro Leal, Joel Rosiene, Marlon Stoeckius, Peter Smibert, William D Travis, Juan Miguel Mosquera
Published: 202510.1038/s41588-025-02418-5
Abstract
DNA damage is preferentially repaired in expressed genes; thus, genome-wide correlations between somatic mutation patterns and normal cell transcription may reflect tumor cell origins. Accordingly, we found that aggregate lung adenocarcinoma (LUAD) a…
Preview only. Read the full abstract at the source