Nature geneticsHumansGene EditingCRISPR-Cas SystemsMutationRNA
Activity-based selection for enhanced base editor mutational scanning.
Eleanor G Kaplan, Ryan J Steger, Spencer T Shah, Laura M Drepanos, Audrey L Griffith, Ganna Reint, John G Doench
Published: 202510.1038/s41588-025-02366-0
Abstract
Base editing is a CRISPR-based technology that enables high-throughput, nucleotide-level functional interrogation of the genome that is essential for understanding the genetic basis of human disease and informing therapeutic development. Base editing…
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