Nature biotechnology
Site-specific DNA insertion into the human genome with engineered recombinases.
Alison Fanton, Liam J Bartie, Juliana Q Martins, Vincent Q Tran, Laine Goudy, Courtney Kernick, Matthew G Durrant, Jingyi Wei, Zev Armour-Garb, April Pawluk, Silvana Konermann, Alexander Marson, Luke A Gilbert, Theodore L Roth, Patrick D Hsu
Published: 202510.1038/s41587-025-02895-3
Abstract
Insertions of large DNA sequences into the genome are broadly enabling for research and therapeutic applications. Large serine recombinases (LSRs) can mediate direct, site-specific genomic integration of multi-kilobase DNA sequences without a pre-ins…
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