Nature biotechnology
Clearance of intracranial debris by ultrasound reduces inflammation and improves outcomes in hemorrhagic stroke models.
Matine M Azadian, Sepideh Kiani Shabestari, Arjun Rajan, Payton J Martinez, Nicholas Macedo, Eric Markarian, Yun Xiang, Brenda J Yu, Paul M George, Ryann M Fame, Raag D Airan
Published: 202510.1038/s41587-025-02866-8
Abstract
Impaired clearance of neurotoxic debris in the brain exacerbates neurologic disease and presents a promising therapeutic target. Pharmacologic therapies can enhance meningeal lymphatic clearance in preclinical models but may be limited by systemic to…
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