Nature biotechnology
Elucidating lipid nanoparticle properties and structure through biophysical analyses.
Marshall S Padilla, Sarah J Shepherd, Andrew R Hanna, Martin Kurnik, Xujun Zhang, Michelle Chen, James Byrnes, Ryann A Joseph, Hannah M Yamagata, Adele S Ricciardi, Kaitlin Mrksich, David Issadore, Kushol Gupta, Michael J Mitchell
Published: 202510.1038/s41587-025-02855-x
Abstract
Designing lipid nanoparticle (LNP) delivery systems with specific targeting, potency and minimal side effects is crucial for their clinical use. However, traditional characterization methods, such as dynamic light scattering, cannot accurately quanti…
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