Nature biotechnology
A trimodal protein language model enables advanced protein searches.
Jin Su, Yan He, Shiyang You, Shiyu Jiang, Xibin Zhou, Xuting Zhang, Yuxuan Wang, Xining Su, Igor Tolstoy, Xing Chang, Hongyuan Lu, Fajie Yuan
Published: 202510.1038/s41587-025-02836-0
Abstract
ProTrek unifies protein sequence, structure and natural language function in a trimodal language model through contrastive learning, enabling comprehensive searches between any two modalities, including within modality. ProTrek surpasses current alig…
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