Nature biotechnology
Deep-learning-based virtual screening of antibacterial compounds.
Gabriele Scalia, Steven T Rutherford, Ziqing Lu, Kerry R Buchholz, Nicholas Skelton, Kangway Chuang, Nathaniel Diamant, Jan-Christian Hütter, Jerome-Maxim Luescher, Anh Miu, Jeff Blaney, Leo Gendelev, Elizabeth Skippington, Greg Zynda, Nia Dickson
Published: 202510.1038/s41587-025-02814-6
Abstract
The increase in multidrug-resistant bacteria underscores an urgent need for additional antibiotics. Here, we integrate small-molecule high-throughput screening with a deep-learning-based virtual screening approach to uncover new antibacterial compoun…
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