Nature biotechnology
Predicting functions of uncharacterized gene products from microbial communities.
Yancong Zhang, Amrisha Bhosle, Sena Bae, Kelly Eckenrode, Xueying Huang, Jingjing Tang, Danylo Lavrentovich, Lana Awad, Ji Hua, Ya Wang, Xochitl C Morgan, Bin Li, Andy Krueger, Wendy S Garrett, Eric A Franzosa
Published: 202510.1038/s41587-025-02813-7
Abstract
The majority of genes in microbial communities remain uncharacterized. Here we develop a method to infer putative function for microbial proteins at scale by assessing community-wide multiomics data. We predict high-confidence functions for >443,000…
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