Nature biotechnology
AlphaDIA enables DIA transfer learning for feature-free proteomics.
Georg Wallmann, Patricia Skowronek, Vincenth Brennsteiner, Mikhail Lebedev, Marvin Thielert, Sophia Steigerwald, Mohamed Kotb, Oscar Despard, Tim Heymann, Xie-Xuan Zhou, Maximilian T Strauss, Constantin Ammar, Sander Willems, Magnus Schwörer, Wen-Feng Zeng
Published: 202510.1038/s41587-025-02791-w
Abstract
The scale of data generated for mass-spectrometry-based proteomics and modern acquisition strategies poses a challenge to bioinformatic analysis. Search engines need to make optimal use of the data for biological discoveries while remaining statistic…
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