Nature
A prophage-encoded abortive infection protein preserves host and prophage spread.
Molly R Sargen, Sadie P Antine, Grzegorz J Grabe, Gabriella Antonellis, Adelyn E Ragucci, Yao Li, Philip J Kranzusch, Sophie Helaine
Published: 202610.1038/s41586-025-10070-6
Abstract
Most bacterial pathogens are polylysogens, harbouring multiple vertically transmitted prophages1-3. These prophages enhance bacterial pathogenicity and survival by encoding virulence factors and anti-phage defence systems while retaining the capacity…
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