Nature
Identification of an allosteric site on the E3 ligase adapter cereblon.
Vanessa N Dippon, Zeba Rizvi, Anthony E Choudhry, Chun-Wa Chung, Ibrahim F Alkuraya, Wenqing Xu, Xavier B Tao, Anthony J Jurewicz, Jessica L Schneck, Wenqian Chen, Nicole M Curnutt, Farah Kabir, Kwok-Ho Chan, Markus A Queisser, Caterina Musetti
Published: 202610.1038/s41586-025-09994-w
Abstract
Cereblon (CRBN) is the target of thalidomide derivatives1 that achieve therapeutic efficacy against some haematologic neoplasias2-4 by recruiting neosubstrates for degradation5-7. Despite the intense investigation of orthosteric thalidomide derivativ…
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