Nature
Fibroblastic reticular cells direct the initiation of T cell responses via CD44.
Xavier Y X Sng, Valentina Voigt, Iona S Schuster, Peter Fleming, Felix A Deuss, Mohammed H Abuwarwar, Serani L H van Dommelen, Georgia E G Neate, Riley M Arnold, Harry L Horsnell, Sheridan Daly, Bagher Golzarroshan, Antiopi Varelias, Stewart D Lyman, Anthony A Scalzo
Published: 202610.1038/s41586-025-09988-8
Abstract
The movement of dendritic cells and T cells within secondary lymphoid organs is critical for the development of adaptive immune responses1,2. Central to this process is the fibroblastic reticular cell (FRC) network, which forms a highly organized con…
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