Nature
Common variation in meiosis genes shapes human recombination and aneuploidy.
Sara A Carioscia, Arjun Biddanda, Margaret R Starostik, Xiaona Tang, Eva R Hoffmann, Zachary P Demko, Rajiv C McCoy
Published: 202610.1038/s41586-025-09964-2
Abstract
The leading cause of human pregnancy loss is aneuploidy, often tracing to errors in chromosome segregation during female meiosis1,2. Although abnormal crossover recombination is known to confer risk for aneuploidy3,4, limited data have hindered under…
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