Nature reviews. Urology
Emerging evidence for sequencing and combining PSMA-based therapies in prostate cancer.
Sola Adeleke, Joao R Galante, Yishen Wang, Gurdip Azad, Simon Wan, Athar Haroon, Diletta Bianchini, Jamshed Bomanji, Michael S Hofman, Travis S Young, Gary J R Cook
Published: 202510.1038/s41585-025-01107-6
Abstract
Prostate-specific membrane antigen (PSMA) is upregulated in prostate cancer cells relative to other cells. The increased expression and enzymatic activity of PSMA in high-stage disease confers a selective advantage on such cells, contributing to thei…
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