Nature reviews. Drug discovery
In vivo chimeric antigen receptor (CAR)-T cell therapy.
Adrian Bot, Andrew Scharenberg, Kevin Friedman, Lin Guey, Robert Hofmeister, James I Andorko, Michael Klichinsky, Frank Neumann, Jagesh V Shah, Andrew J Swayer, Kyle Trudeau, Drew Weissman, Matthias T Stephan, Christian J Buchholz, Carl H June
Published: 202510.1038/s41573-025-01291-5
Abstract
Chimeric antigen receptor (CAR)-T cell therapy has transformed the outcomes of patients with haematological malignancies, yet its use is limited by labour-intensive manufacturing, constrained production capacity and variable clinical performance. In…
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