Nature reviews. Clinical oncology
The quintessential role for CAR T cell therapy in children, adolescents and young adults with cancer.
Liora Schultz, Kevin McNerney, Adam J Lamble, Friso G Calkoen, Andre Baruchel, Francesco Ceppi, Kevin J Curran, Lia Gore, Margaret Lamb, Shannon L Maude, Michael A Pulsipher, Muna Qayed, Sneha Ramakrishna, Susan R Rheingold, Claudia Rossig
Published: 202610.1038/s41571-025-01115-w
Abstract
Early successes achieved with the CD19-targeted chimeric antigen receptor (CAR) T cell product tisagenlecleucel for the treatment of paediatric B cell acute lymphoblastic leukaemia (B-ALL) led to a historic first FDA approval of a gene therapy. Wides…
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