Nature nanotechnologyInfluenza VaccinesLipidsAnimalsRNAMessenger
Degradable cyclic amino alcohol ionizable lipids as vectors for potent influenza mRNA vaccines.
Arnab Rudra, Akash Gupta, Kaelan Reed, Amy Deik, Jiyeon Min, Hasan Mansour A Mansour, Quang Trung Chinh Nguyen, Austin Danko, Yizong Hu, Allegra Berger, Michaela Prado, Amira Beck, Clary B Clish, Jeffery B Klauda, Robert Langer
Published: 202510.1038/s41565-025-02044-6
Abstract
The next generation of mRNA vaccines must address several limitations, including enhancing vaccine potency and reducing toxicity. Here we develop a class of degradable, cyclic amino ionizable lipids via sequential combinatorial chemistry and rational…
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