Nature nanotechnologyPhosphorusMitochondriaImmunotherapyAnimalsMice
Black phosphorus nanosheets boost mitochondrial oxidative phosphorylation improving immunotherapy outcomes.
Yuedi Yang, Mingda Zhao, Jiadong Li, Ruiling Xu, Jie Liang, Qing Jiang, Xingchen Peng, Aiping Tong, Li Min, Yunfeng Lin, Xingdong Zhang, Yujiang Fan, Yong Sun
Published: 202510.1038/s41565-025-02022-y
Abstract
Regulating intracellular phosphorus may affect multiple biosynthetic processes and modulate cancer cell progression. Here we show that exogenous PEGylated black phosphorus nanosheets (BPP) are metabolized into phosphate in tumor cells, where they boo…
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