Nature microbiologyStreptococcus pneumoniaePeptidoglycanPenicillin-Binding ProteinsCell DivisionBacterial Proteins
Streptococcus pneumoniae S protein activates PBP1a to regulate peptidoglycan remodelling and cell division.
Hugo Millat, Cassandra Falcou, Cassandra Lenoir, Nicholas S Briggs, Jack Stone, Pierre Simon Garcia, Sylvie Manuse, Caroline Cluzel, André Zapun, Cécile Morlot, David I Roper, Adrien Ducret, Christophe Grangeasse
Published: 202610.1038/s41564-025-02210-5
Abstract
Class A penicillin-binding proteins (aPBPs) are involved in the biosynthesis and remodelling of peptidoglycan (PG). The human bacterial pathogen Streptococcus pneumoniae produces three aPBPs, which are regulated to maintain the bacterium's ovoid shap…
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