Nature materials
Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells.
Valentin Gensbittel, Zeynep Yesilata, Louis Bochler, Gautier Follain, Laurie Nemoz-Billet, Olivier Lefebvre, Klemens Uhlmann, Annabel Larnicol, Giulia E M Ammirati, Sébastien Harlepp, Ruchi Goswami, Salvatore Girardo, Laetitia Paulen, Vincent Hyenne, Vincent Mittelheisser
Published: 202610.1038/s41563-025-02462-w
Abstract
Metastases arise from a multistep process during which tumour cells face several microenvironmental mechanical challenges, which influence metastatic success. However, how circulating tumour cells (CTCs) adapt their mechanics to such microenvironment…
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