Nature chemistry
Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3.
Elisabeth Hennes, Belén Lucas, Natalie S Scholes, Xiu-Fen Cheng, Daniel C Scott, Matthias Bischoff, Katharina Reich, Raphael Gasper, María Lucas, Teng Teng Xu, Sofia Rossini, Lisa-Marie Pulvermacher, Lara Dötsch, Hana Imrichova, Alexandra Brause
Published: 202610.1038/s41557-025-02021-5
Abstract
Targeted protein degradation modulates protein function beyond the inhibition of enzyme activity or protein-protein interactions. Most degrader drugs function by directly mediating the proximity between a neosubstrate and a hijacked E3 ligase. Here w…
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