Nature chemistry
Direct enantioselective C(sp3)-H coupling of N-alkyl anilines via metallaphotoredox catalysis.
Weisai Zu, Xiang Wan, Haoran Wu, Jingwen Huo, Cankun Zhang, Chengyang Li, Yongliang Huang, Zhen Xu, Yumin Xu, Tao Li, Junliang Cheng, Jian-Liang Ye, Cheng Wang, Haohua Huo
Published: 202610.1038/s41557-025-02018-0
Abstract
Amine functionalization is crucial in pharmaceutical and agrochemical synthesis yet direct enantioselective α-C(sp3)-H functionalization of N-alkyl anilines remains challenging. Here we show a metallaphotoredox-catalysed radical approach for α-C(sp3)…
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