Nature chemistry
Global profiling of arginine reactivity and ligandability in the human proteome.
Yuena Wang, Tao Hu, Lin Zhu, Shaoshuai Xie, Xi Yang, Caifeng Xu, Yansheng Zhai, Youming Li, Xiaoyan Huang, Bo Yang, Gang Li
Published: 202610.1038/s41557-025-02012-6
Abstract
Despite the crucial biological functions of arginine, its reactivity and ligandability within the human proteome remain largely unexplored. Here we apply activity-based protein profiling (ABPP) with phenylglyoxal-based chemical probes to map arginine…
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