Nature chemistry
Iridium(III)-catalysed ionic hydrogenation of pyridines to multisubstituted piperidines.
Arthur Despois, Nicolai Cramer
Published: 202510.1038/s41557-025-02008-2
Abstract
Piperidine and pyridine are nitrogen heterocyclic motifs prominently used in pharmaceuticals and consequently of great importance. The direct reduction of planar pyridines into piperidines with high sp3-carbon content is highly attractive as this off…
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