Nature chemistry
Triply convergent Ni-electrocatalytic assembly of 1,1-diaryl cyclobutanes, azetidines and oxetanes.
Luca Massaro, Philipp Neigenfind, Andrew Feng, Gannon Kuehn, Flynn C Attard, Ava DeSanti, Michael R Collins, Martin Bravo, Raymond K Twumasi, Doris Chen, Philippe N Bolduc, Michael Nicastri, Megan A Emmanuel, Martins S Oderinde, Maximilian D Palkowitz
Published: 202510.1038/s41557-025-01990-x
Abstract
The pursuit of increasingly complex, three-dimensional molecules is pushing the boundaries of modern organic synthesis, particularly in drug discovery where rigid, saturated scaffolds such as cyclobutanes, azetidines and oxetanes are in high demand.…
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