Nature cell biology
RPA exhaustion activates SLFN11 to eliminate cells with heightened replication stress.
Tyler H Stanage, Shudong Li, Sandra Segura-Bayona, Aurora I Idilli, Rhona Millar, Graeme Hewitt, Simon J Boulton
Published: 202610.1038/s41556-025-01852-1
Abstract
SLFN11 is epigenetically silenced and confers chemoresistance in half of all cancers. In response to replication stress, SLFN11 triggers translation shutdown and p53-independent apoptosis, but how DNA damage activates SLFN11 remains unclear. Here thr…
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