Nature cell biologyGerminal CenterAnimalsB-LymphocytesImmunityHumoral
T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response.
Laurianne Scourzic, Franco Izzo, Matt Teater, Alexander P Polyzos, Lucretia Cucereavii, Christopher R Chin, Antonin Papin, Hugo B Pinto, Coraline Mlynarczyk, Ioanna Tsialta, Min Xia, Abigail Lidoski, Robert M Myers, Eva M Israel, Leandro Venturutti
Published: 202610.1038/s41556-025-01833-4
Abstract
During the germinal centre (GC) reaction, mature B cells undergo rapid and reversible phenotypic shifts that are essential for adaptive immunity. Here we report that GC B cells, unlike other mature B cells, transiently acquire a unique epigenetic pla…
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