Nature cell biologyHumansChromatinTumor Necrosis Factor-alphaGene Expression RegulationInflammation
Two distinct chromatin modules regulate proinflammatory gene expression.
Isabelle Seufert, Irene Gerosa, Vassiliki Varamogianni-Mamatsi, Anastasiya Vladimirova, Ezgi Sen, Stefanie Mantz, Anne Rademacher, Sabrina Schumacher, Panagiotis Liakopoulos, Petros Kolovos, Simon Anders, Jan-Philipp Mallm, Argyris Papantonis, Karsten Rippe
Published: 202610.1038/s41556-025-01819-2
Abstract
Gene activation and coregulation have been attributed to different mechanisms, such as enhancer-promoter interactions via chromatin looping or the accumulation of transcription factors into hubs or condensates. However, genome-wide studies exploring…
Preview only. Read the full abstract at the source