Nature cell biologyHumansMelaninsKeratinocytesIntermediate FilamentsUltraviolet Rays
Keratin intermediate filaments mechanically position melanin pigments for genome photoprotection.
Silvia Benito-Martínez, Laura Salavessa, Anne-Sophie Macé, Myckaëla Rouabah, Nathan Lardier, Vincent Fraisier, Julia Sirés-Campos, Riddhi Atul Jani, Maryse Romao, Vanessa Roca, Charlène Gayrard, Marion Plessis, Ilse Hurbain, Cécile Nait-Meddour, Sandrine Etienne-Manneville
Published: 202610.1038/s41556-025-01817-4
Abstract
Melanin pigments block genotoxic agents by positioning on the sun-exposed side of the nucleus in human skin keratinocytes. How this positioning is regulated and its role in genome photoprotection remain unknown. Here, by developing a model of human k…
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