Nature cell biologyHumansProto-Oncogene Proteins p21(ras)AnimalsSignal TransductionMutation
RASH3D19 mediates RAS activation through a positive feedback loop in KRAS-mutant cancer.
Warapen Treekitkarnmongkol, Hiroshi Katayama, Deivendran Sankaran, Mei-Chee Tai, Sanchita Rauth, Hanxiao Chen, Tristian Nguyen, Kieko Hara, Fredrik I Thege, Moorthy P Ponnusamy, Surinder K Batra, Huamin Wang, Ignacio I Wistuba, Thomas D Schmittgen, John V Heymach
Published: 202610.1038/s41556-025-01816-5
Abstract
Therapeutic targeting of mutant KRAS pathways driving cancers is being actively investigated to identify feedback mechanisms responsible for the development of adaptive resistance to mutant KRAS inhibitors undergoing clinical trials. Here we report R…
Preview only. Read the full abstract at the source