Nature cell biologyAnimalsFemaleMaleNeuronsProteome
Chaperone-mediated autophagy regulates neuronal activity by sex-specific remodelling of the synaptic proteome.
Rabia R Khawaja, Ernesto Griego, Kristen Lindenau, Asma Salek, Jessica Gambardella, Aurora Scrivo, Hannah R Monday, Mathieu Bourdenx, Jesús Madero-Pérez, Zohaib N Khan, Bhakti Chavda, Ronald Cutler, Sarah Graff, Simone Sidoli, Gaetano Santulli
Published: 202510.1038/s41556-025-01771-1
Abstract
Chaperone-mediated autophagy (CMA) declines in ageing and neurodegenerative diseases. Loss of CMA in neurons leads to neurodegeneration and behavioural changes in mice but the role of CMA in neuronal physiology is largely unknown. Here we show that C…
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