Nature biomedical engineering
High-efficiency TadA cytosine base editors for precise modelling of human disease variants.
Wei Qin, Sheng-Jia Lin, Yu Zhang, Kevin Huang, Cassidy Petree, Pratishtha Varshney, Gaurav K Varshney
Published: 202610.1038/s41551-025-01607-1
Abstract
Many missense mutations identified in genetic testing are variants of uncertain significance (VUS), not yet classified as either benign or pathogenic. Systematic determination of their functional relevance is a pressing clinical need. CRISPR-mediated…
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