Nature biomedical engineering
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors.
Jose Cabezas-Caballero, Anna Huhn, Mikhail A Kutuzov, Violaine Andre, Alina Shomuradova, Bas W A Peeters, Geraldine M Gillespie, P Anton van der Merwe, Omer Dushek
Published: 202610.1038/s41551-025-01563-w
Abstract
Adoptive T cell therapy using T cells engineered with novel T cell receptors (TCRs) targeting tumour-specific peptides is a promising immunotherapy. However, these TCR-T cells can cross-react with off-target peptides, leading to severe autoimmune tox…
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