Nature biomedical engineering
Engineering a macromolecular JAK inhibitor for treating acute inflammation and endotoxaemia.
Min Zhou, Yan Wang, Bin Yang, Yang Zhang, Ling Zhong, Kaiyao Hu, Wendan Pu, Gaoxing Luo, Jianxiang Zhang
Published: 202510.1038/s41551-025-01521-6
Abstract
Uncontrolled and sustained inflammation is inextricably associated with the pathogenesis of numerous diseases. However, there is still demand for effective and safe anti-inflammatory therapies. Here we report a potent anti-inflammatory macromolecular…
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