Nature biomedical engineering
A HO-1 gene knockout using a NanoCRISPR scaffold suppresses metastasis in mouse models.
Ning Wang, Zichao Luo, Chao Liu, Jialin Ma, Xinyue Wu, Qinjie Wu, Xiaogang Liu, Changyang Gong
Published: 202510.1038/s41551-025-01518-1
Abstract
Photodynamic therapy-induced immunogenic cell death has the potential to generate autologous cancer vaccines. However, the innate or evolved genetic tolerance of tumours limits the efficacy of this approach. Here we report the development of a herita…
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