Nature biomedical engineering
Staple oligomers induce a stable RNA G-quadruplex structure for protein translation inhibition in therapeutics.
Yousuke Katsuda, Takuto Kamura, Tomoki Kida, Rinka Ohno, Shuhei Shiroto, Yua Hasegawa, Kaito Utsumi, Yuki Sakamoto, Shinichiro Nakamura, Taishi Nakamura, Kenichi Tsujita, Yusuke Kitamura, Yukiko Kamiya, Hiroyuki Asanuma, Toshihiro Ihara
Published: 202510.1038/s41551-025-01515-4
Abstract
Gene-silencing mechanisms using RNA interference (RNAi) and antisense oligomers have drawn attention to nucleic acid medicines. However, several challenges remain such as low in vivo stability and inadequate target selectivity. Here we report a versa…
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