Nature biomedical engineering
Targeting circulating mechanoresponsive monocytes and macrophages to reduce fibrosis.
Kellen Chen, Michelle Griffin, Dominic Henn, Katharina S Berryman, Dharshan Sivaraj, Hudson C Kussie, Clark A Bonham, Eamonn McKenna, Maria Gracia Mora Pinos, Abdelrahman M Alsharif, Fidel Saenz, Nicholas E Matthews, Maisam Jafri, Jonathan P Yasmeh, Mimi R Borrelli
Published: 202510.1038/s41551-025-01479-5
Abstract
In response to injury, a variety of different cells are recruited to sites of injury to facilitate healing. Recent studies have examined the importance of the heterogeneity of tissue resident fibroblasts and mechanical signalling pathways in healing…
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