NPJ Parkinson's disease
UQCRC1 deficiency impairs mitophagy via PINK1-dependent mechanisms in Parkinson's disease.
Jeng-Lin Li, Shu-Yi Huang, Po-Yu Huang, Ssu-Ju Fu, Yu-Jung Tsao, Wenying Chang, Cheng-Li Hong, Yu-Chien Hung, Pei-Han Liu, Liang-Chuan Lai, Chin-Hsien Lin, Wei-Chung Chiang, Chih-Chiang Chan
Published: 202610.1038/s41531-026-01262-6
Abstract
Oxidative phosphorylation (OXPHOS) and mitophagy are functionally interconnected cellular processes, the defects of which are considered key driving forces behind the pathogenesis of Parkinson's disease (PD). UQCRC1, a core subunit of the mitochondri…
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