NPJ Parkinson's disease
Early retinal synaptic dysfunction and proteomic remodeling precede neurodegeneration in a Parkinson's disease model.
Chae-Eun Moon, Seung Jae Lee, Haesol Shin, Hongkyung Kim, Jun-Ki Lee, Hyunjin Kim, Hyun Seung Kang, In Hee Moon, Sung Soo Kim, Hyung Keun Lee, Kyoung Yul Seo, Sung-Rae Cho, Yong Woo Ji
Published: 202610.1038/s41531-026-01261-7
Abstract
Parkinson's disease (PD) affects motor and non-motor systems; however, retinal changes and their molecular basis are not well understood. Using a transgenic mouse model overexpressing A53T-mutant human α-synuclein, we examined retinal function, struc…
Preview only. Read the full abstract at the source