NPJ Parkinson's disease
Spatial single-cell multiomics reveals peripheral immune dysfunction in Parkinson's and inflammatory bowel disease.
MacKenzie L Bolen, Marc Buendia, Ji Shi, Hannah Staley, Jennifer M Kachergus, Philip A Efron, Gwoncheol Park, Ravinder Nagpal, Stephan D Alvarez, Qing-Shan Xue, Nikolaus R McFarland, Ellen M Zimmermann, Christopher E Forsmark, Kelly B Menees, Azucena Salas
Published: 202610.1038/s41531-025-01199-2
Abstract
Parkinson's disease (PD) is the fastest-growing neurodegenerative disease in the world1. Gastrointestinal (GI) dysfunction can occur decades before motor impairments and in up to 80% of individuals living with PD2-4. We investigated peripheral relati…
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