Assessing prevalence and risk factors for REM sleep behavior disorder among patients with inflammatory bowel disease.

REM sleep behavior disorder (RBD) and inflammatory bowel disease (IBD) are associated with Parkinson's Disease. Using a cross-sectional design, we assessed RBD prevalence in IBD and controls. In total, 158 controls and 462 IBD patients completed IBD-related history questionnaires, the RBD Single-Question Screen (RBD1Q), and the RBD-Screening Questionnaire. RBD prevalence was compared using chi-squared testing. Logistic regression explored IBD-related factors associated with RBD (RBD1Q), adjusting for age, sex, race, and antidepressant usage. RBD prevalence was higher in IBD (14.1% vs. 5.1%; P = 0.002), driven by differences in women; 13.3% IBD and 1.0% controls had RBD. Among men, 16.0% IBD and 11.9% controls had RBD. IBD was associated with >threefold RBD odds (OR = 3.08, 95% CI [1.43, 6.62], P = 0.003). Men with RBD and IBD had higher IBD-related hospitalization rates than IBD males without RBD (95.2% vs. 63.0%; P = 0.004). RBD is more prevalent in IBD than in controls and is associated with severe IBD.