NPJ biofilms and microbiomes
Microbiome dysbiosis and chemotherapy resistance in acute myeloid leukemia (AML).
Maojin Tian, Hamed Soleimani Samarkhazan, Seyed Shahabedin Alemohammad, Milad Fakhraei Manesh, Farzaneh Tavakoli, Ali Shams, Amirhossein Zeynalabadi
Published: 202510.1038/s41522-025-00891-8
Abstract
AML often relapses due to chemotherapy resistance, increasingly linked to gut microbiome dysbiosis. Microbial drug modification, immune modulation, and metabolite-driven survival/epigenetic changes (e.g., SCFAs, kynurenine) promote resistance. Clinic…
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