Nature communications
Chemically guided single-cell transcriptomics reveals sulfotransferase-mediated scaffold remodeling in securinine biosynthesis.
Sungjun Choung, Gyumin Kang, Taein Kim, Seoyoung Kim, Hyejung Yun, Yeojin Hwang, Hyeonjin Kim, Hangah Lim, Kwanyoung Moon, Sunkyu Han, Sang-Gyu Kim
Published: 202610.1038/s41467-026-68816-3
Abstract
Securinega alkaloids possess a distinctive tetracyclic scaffold and are pharmaceutically relevant, yet their biosynthesis in Flueggea suffruticosa remains unresolved. Here, we combine chemical logic with stable-isotope-labeled feeding experiments and…
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