Nature communications
Endothelial PDLIM5 promotes tip cell filopodia formation and tumor angiogenesis by regulating ACTN1/ACTN4-dependent actin bundling.
Zhiyong Xu, Yueli Shi, Yan Yang, Bufu Tang, Jiangnan Zhao, Mingshu Xiao, Sujing Jiang, Xinyuan Jiang, Nueraili Maihemuti, Kaiyue Zhang, Huan Wang, Yun Xu, Yuchao Sun, Xiuying Chen, Peng Xiao
Published: 202610.1038/s41467-026-68765-x
Abstract
Filopodia formation by tumor endothelial cells (TECs) is critical for tip cell-guided sprouting angiogenesis and tumor growth. However, the cytoskeletal organization that underlies this process remains elusive. Here, we demonstrates that TECs highly…
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