Nature communications
Silencing lipid catabolism determines longevity in response to fasting.
Lexus Tatge, Juhee Kim, Rene Solano Fonseca, Kyle Feola, Jordan M Wall, Gupse Otuzoglu, Ann C Johnson, Kielen R Zuurbier, Jaeyoung Oh, Shaghayegh T Beheshti, Victor A Lopez, Anthony J Daley, Emma G Werner, Patrick Metang, Sonja L B Arneaud
Published: 202610.1038/s41467-026-68764-y
Abstract
Oscillations between lipid anabolism and catabolism are essential for maintaining cellular health during metabolic fluctuations. Fasting, a conserved determinant of aging, improves disease outcomes and extends lifespan, yet the relative contributions…
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