Nature communications
Structural basis for fork reversal and RAD51 regulation by the SCF ubiquitin ligase complex of F-box helicase 1.
Briana H Greer, Javier Mendia-Garcia, Elwood A Mullins, Emma M Peacock, Sander K Haigh, Carl J Schiltz, Clara Aicart-Ramos, Miaw-Sheue Tsai, David Cortez, Fernando Moreno-Herrero, Brandt F Eichman
Published: 202610.1038/s41467-026-68752-2
Abstract
Replication fork reversal helps maintain genomic stability during replication stress. F-box helicase 1 (FBH1) catalyzes fork reversal and is an SCF (SKP-CUL1-F-box) E3 ubiquitin ligase that limits RAD51 association with chromatin. Here, we show that…
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